A solitary plasmacytoma is an isolated tumor located either in the bone (spine or long bone) or in other organs (upper digestive organs and respiratory tract). The detection age is 50-60 years, clinical signs are palpation of a lump or pain in the area of the tumor.

A full body scanner and MRI are usually performed to confirm the presence or absence of other lesions associated with the primary tumor. A biopsy of the puncture of the lesion is performed to confirm the diagnosis. The tumor consists of abnormal plasma cells. Plasmacytoma can progress within 2–3 years to multiple myeloma in more than half of patients.

In the process of evolution of the disease, there is no involvement of bone marrow. There is no anemia, normal phosphocalcium balance, normal kidney function, normal spinal cytology.

Electrophoresis of plasma proteins may show an increase in monoclonal M Ig, proteinuria is also performed for diagnosis. The reference treatment is radiotherapy with modulation of the intensity of the lesion, as a rule, with a total dose of 44 Gy in 22 fractions of 2 Gy.
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